Denosumab is contraindicated in women with hypocalcaemia. have low blood calcium; or are pregnant or plan to become pregnant, as Prolia may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia. You may be interested in learning how Prolia compares to the medication Fosamax. Costs of prescription drugs can vary depending on many factors. Your doctor should examine your mouth before you start Prolia and may tell you to see your dentist. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). Call your doctor at once if you have a fever, chills, pain or burning when you urinate, severe stomach pain, cough, shortness of breath, skin problems, numbness or tingling, severe or unusual pain, or skin problems. Continue reading, Yes, Prolia does appear to weaken your immune system. Your doctor will recommend the dosage of Prolia thats right for you. Prolia also carries a warning about hypocalcemia, which is a low level of It is often used in osteoporosis. If you have a low calcium level, you should not take Prolia. The drug could cause your calcium level to drop too low. for prostate cancer that has not spread to other parts of the body. All information is observation-only. If youd like a detailed comparison of Prolia versus Boniva, view this article. Available for Android and iOS devices. There arent any studies that have compared these two drugs to each other. Web You will receive Prolia 1 time every 6 months. Over time, Prolia helps to improve the density and strength of your bones by slowing bone loss. Your risk for having more than 1 broken bone in your spine is increased if you have already had a broken bone in your spine. These side effects include: Your risk for these serious side effects may be higher if youre older and have certain dental procedures. Osteoporosis medications and medication-related osteonecrosis of the jaw. Pay special attention to your dental hygiene. Prolia and Xgeva both contain the active drug denosumab, but they are not approved to treat all of the same conditions. If youve noticed hair loss since starting Prolia treatment, talk with your doctor. Pregnancy. Fracture in the spine after stopping Prolia treatment. In certain cases, Prolia may have contraindications (not be recommended) for you due to a higher risk for side effects. The drug may also be used off-label for osteopenia, but usually, you dont need medications for osteopenia. While you are using Prolia, you should not receive Xgeva, another brand of denosumab. Having dental procedures, including tooth extractions, during Prolia treatment may increase your risk of dental side effects. Prolia may cause serious side effects. But its not clear whether this side effect occurred in clinical studies. For more information about how these medications compare with each other, ask your doctor. It is not safe to receive Prolia during pregnancy. have happened in people who take Prolia. Prolia and Evenity are both biologic medications, but Prolia contains the active drug denosumab, while Evenity contains the active drug romosozumab-aqqg. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. You should take calcium and vitamin D as your doctor tells you to while you receive Prolia. Adults over age 50 should not exceed 2,000 mg total per day. There arent any reported interactions between Prolia and alcohol. What should I know about Prolia vs. Fosamax? Allergic reaction. All rights reserved. Our phase IV clinical studies alone cannot establish cause-effect relationship. WebDrug interactions are reported among people who take Prolia and Calcium. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. They may give you tips on managing a body weight thats healthy for you. For more information, you can refer to the drugs prescribing information. In this article well discuss the uses, side effects, safety precautions, and other important information about Prolia. Prolia may not be right for you if you have certain medical conditions or other factors that affect your health. Your low blood calcium must be treated before you receive Prolia. Keep out of the reach of children and pets. Compared to other osteoporosis treatments, only Proliais1 shot every 6 months. (Biosimilars are like generic drugs. Courtney Sullivan, Certified Yoga Instructor, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT. Theyll do this with certain tests, such as a bone scan or ultrasound. You should receive your missed injection as soon as possible. You may have questions about Prolia and your treatment plan. Throw away a prefilled syringe after one use, even if there is still medicine left inside. After you stop taking Prolia, youre more likely to experience bone loss, and your risk of a vertebral fracture increases. Here are some frequently asked questions about the drugs side effects and their answers. The most common side effects of Prolia in patients receiving certain treatments for prostate or breast cancer are joint pain, back pain, pain in your arms and legs, and muscle pain. But unlike generics, which are made for nonbiologic drugs, biosimilars are made for biologic drugs.) The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Learn how to increase or maintain bone density here. Your doctor can provide more information to you about the benefits and risks of using Prolia for your condition. Specifically, Prolia is a monoclonal antibody (a lab-made protein). But if you look at D3 supplements online, youll see that most commercial supplements have higher doses usually either 1,000, 2,000, 5,000 or 10,000 IU. Some people have developed unusual fractures in their thigh bone. To date, the consensus is that there has been no proven risk of increased cardiovascular risk with intake of calcium supplements. Other drugs that have the same active ingredients (e.g. Your doctor may also recommend other treatments with Prolia to help increase your bone mass. These include osteonecrosis of the jawbone. Visit www.fda.gov/medwatch, orcall1-800-FDA-1088. MNT is the registered trade mark of Healthline Media. They will also explain how much youll be given and how often. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. (Biologic medications are made from living organisms.). If your pain is more severe, your doctor may suggest prescription pain medication or physical therapy. You should also talk with your doctor if you have nausea during treatment. But its not clear how often this side effect occurred in clinical trials. Coral calcium is also used in maxillofacial surgery and bone grafting. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. If youre pregnant or breastfeeding, or considering either, talk with your doctor. Any advice? All subjects in the clinical trials of Prolia received 800mg of calcium and Prolia contains the active drug denosumab, and Reclast contains the active drug zoledronic acid. And some of these side effects are more common with certain uses of Prolia. What should I know about Prolia vs. Evenity? However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. If you notice any tooth or jaw pain, or sensitivity while using Prolia, talk with your doctor or dentist right away. Various types of osteoporosis medications are available. 1 shot every 6 months could mean fewer doses. They can also happen if you have certain conditions or if you take certain medications. Below, we answer some common questions about taking Prolia. Learn more about some of the side effects Prolia may cause. Its important to discuss all your concerns with your doctor. An allergic reaction is possible after using Prolia. Over time, Prolia can reduce bone loss and make your bones stronger. NOTE: This sheet is a summary. Specifically, its used to increase bone mass in: Osteopenia (low bone mass), and low bone mineral density (BMD) can occur with older age. Do not treat yourself. Prolia also carries a warning about hypocalcemia, which is a low level of calcium in the blood. You can use the study as a second opinion to make health care decisions. Please know that the sponsors of this site are not responsible for content on the site you are about to enter. Your healthcare professional might talk to you about taking a calcium or vitamin D supplement, although generally its better to get enough of each from your diet. Your doctor may also have you take certain supplements that contain calcium and vitamin D while youre receiving Prolia. Mild side effects of Prolia that have been reported include: Mild side effects of many drugs may go away within a few days or a few weeks. Be sure to talk with your doctor about which medication is right for you. Your doctor may have you take extra calcium and vitamin D while you are being treated with Prolia. But if youre planning to have surgery, you may need to take a break If youre concerned about side effects with Prolia, talk with your doctor. You may report side effects to FDA at 1-800-FDA-1088. Talk with your doctor or health care professional about your birth control options while taking this medicine. Version: 13.01. hydrochlorothiazide, alendronate, Fosamax, calcium carbonate, Premarin, Tymlos. Monoclonal antibodies are made to target and destroy only certain cells in the body. (To learn more, see the Precautions for Prolia section below.). You should take calcium and vitamin D as your doctor tells you to while you receive Prolia. Use of the term male in this article refers to sex assigned at birth. Prolia can also cause low calcium levels. This is called hypocalcemia. Q: Does AlgaePlus Increase Bone Mass? Serious side effects of Prolia that have been reported include: For most people, Prolias side effects are mild and go away after a few days to a few weeks. If you dont understand something related to your condition or treatment, ask your doctor to explain it to you. Some examples are atorvastatin (Lipitor) and rosuvastatin (Crestor). Your dentist may have you use a chlorhexidine mouth rinse before and after surgery to reduce your risk for jaw-related side effects. Prolia is a medicine that may affect the ability of your body to fight infections. Boniva contains the active drug ibandronate, but Prolia contains the active drug denosumab. You will receive your Prolia injection from your healthcare provider at a their office or clinic. What are the possible side effects of Prolia? You may take the carton out of the refrigerator and allow it to reach room temperature before the injection is given. Prolia is an injection prescribed for certain adults with osteoporosis, which Do not become pregnant while taking this medicine or for 5 months after stopping it. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist. Prolia is meant to be used in combination with calcium and vitamin D supplements. Studies of Prolia didnt report weight gain as a side effect of the drug. 2023 eHealthMe.com. What should I know about Prolia vs. Reclast? Its a prescription drug thats used to treat osteoporosis and other forms of bone loss. 2,4. Instead, it belongs to a different group of medications called biologics. It does the same thing that. Youll receive Prolia doses from a healthcare professional. If youd like to learn more about Prolia, talk with your doctor or pharmacist. Factors to consider include those in the list below. With these reports, it wasnt known whether Prolia or something else (such as a different medication) caused the hair loss. Another common osteoporosis medication is denosumab (Prolia, Xgeva). So be sure to talk with your doctor about any past or upcoming surgery before starting treatment with the drug. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. A solid routine can help to strengthen your muscles and bones, which helps to lower your, If you have osteoporosis, diet plays a vital role in managing your condition. Fatigue (low energy) and nausea werent specifically reported as side effects in clinical trials of Prolia. Prolia is a prescription medicine used to treat bone loss in men who are at high risk for fracture receiving certain treatments Its not known if Prolia is safe or effective for use in children. For information about the difference between sex and gender, see this article. Common side effects of this osteoporosis treatment injection include muscle, joint, and back pain. you can take. Prolia injections administered by a healthcare professional. WebTake calcium and vitamin D as directed by your doctor, usually 1000 milligrams of calcium and at least 400 IU of vitamin D daily. It may not cover all possible information. If youd like to know more about the differences and similarities of Prolia and Evenity, see this comparison. People who have weakened immune systems or take medicines that affect the immune system may have an increased risk for developing serious infections. to treat osteoporosis in males* and in females* whove gone through, to treat osteoporosis caused by long-term use of, metabolic bone disease, such as Hajdu-Cheney syndrome and juvenile. You should use an effective method of birth control (contraception) during treatment with Prolia and for at least 5 months after your last dose of Prolia. Theyre commonly used to treat osteoporosis. Women going through menopause have a higher risk of developing osteoporosis. Whats the Connection Between Estrogen and Osteoporosis? You should not take Prolia if youve ever had an allergic reaction to Prolia or any of its ingredients. Dosage of drugs is not considered in the study. such as inflammation of your skin (dermatitis), rash, and eczema have been reported. Its also recommended that you use birth control while taking Prolia and for 5 months or more after your last dose. You should always consult your doctor or another healthcare professional before taking any medication. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. Prolia is also available in a biosimilar form. generic drugs) are not considered. Call your doctor at once if you have: new or unusual pain in your thigh, hip, or groin; severe pain in your joints, muscles, or bones; skin problems such as dryness, peeling, redness, itching, blisters, bumps, oozing, or crusting; or. low calcium level--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes). WebYou should take calcium and vitamin D as your doctor tells you to while you receive Bone pain from Prolia may be most noticeable in your arms and legs. This aids in keeping your calcium level within the recommended range. If they find any cavities or infection, theyll typically delay having you receive Prolia until your dental problems are treated. But, in some cases, alcohol can affect your balance and increase your risk for falls. Talk with your doctor about which medication is right for you. WebStudies have shown that people who live more sedentary lifestyles are at an increased risk of developing osteoporosis. Vertigo (dizziness) was reported in some females* using Prolia for osteoporosis. Others may continue for as long as you take the drug, but they can be easily managed. DENOSUMAB (den oh sue mab) slows bone breakdown. Prolia is used in adults to treat osteoporosis or bone loss in people who: who cannot use another osteoporosis medicine or these medicines did not work well. Bone density decreases with time, and some people have a risk of developing weak or brittle bones. Prolia is a RANKL inhibitor. Protect from light and do not freeze. Although its rare, your doctor may give you the option to self-inject Prolia at home. But weight gain may be a symptom of a side effect called peripheral edema. The drug stays in your system and continues to slow bone breakdown over this period of time. Prolia can also cause bones to not form correctly and reduced growth in a fetus. Is the ketogenic diet right for autoimmune conditions? Tingling or numbness in the hands, feet, and face can develop as a symptom of severe hypocalcemia. Discuss the foods you eat and the vitamins you take with your health care professional. A special MedGuide will be given to you before each treatment. Youll receive Prolia from a healthcare professional as an injection under the skin in one of the following areas: Prolia contains the active drug denosumab, which is a biologic medication. Youll likely have questions about your condition and treatment choices. This lowers your risk for bone fractures. Use of the terms female and male in this article refers to sex assigned at birth. This drug may not be the right treatment for your condition if you have certain medical conditions or other factors that affect your health. Kidney problems. If youre able to become pregnant, your doctor will have you take a pregnancy test before you start Prolia treatment. This medication guide provides information about the Prolia brand of denosumab. There is a potential for serious side effects to an unborn child. A biologic drug is made from parts of living organisms. Prolia contains the active drug denosumab, while Fosamax contains the active drug alendronate. Call your doctor right away if you have signs of infection such as: swelling, pain, tenderness, warmth, or redness anywhere on your body; pain and burning when you urinate, painful urination; bladder infection (painful or difficult urination); lung infection (cough, shortness of breath); cold symptoms such as stuffy nose, sneezing, sore throat; This is not a complete list of side effects and others may occur. Your FRAX score is your risk of having an osteoporosis-related fracture in the next 10 years. Do not share this medicine with others. So your healthcare provider will likely ask you to take calcium and vitamin D supplements if youre not taking them already. Based on your dental history, your doctor can discuss with you the risks of using Prolia. Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Prolia comes as a solution thats given as an injection under your skin. (such as prednisone) for at least six months and are at high risk for fracture. * Sex and gender exist on spectrums. Do not share this medicine with another person, even if they have the same symptoms you have. They might also recommend physical therapy, massage therapy, or using a heating pad. that's no different than scheduling a visit to the dentist twice a year. Do not reuse a needle or syringe. Prescribing Information and Sciatica was a less common side effect in females* who received Prolia for osteoporosis after menopause. Yoga for Osteoporosis: 5 Beneficial Poses, Diet and Osteoporosis: Nutrients, Diet Tips, and More. This increases your risk for bone fractures. Theyll likely suggest other treatment options for your condition. No one in clinical trials of Prolia had to stop taking the drug due to dizziness. For Prolia, talk to your pediatrician regarding the use of this medicine in children. Prolia contains the active ingredient denosumab. Some people who take Prolia develop severe bone, joint, or muscle pain. Calcium supplements may help support bone and teeth health. Forteo is given as a self-injection once daily. While youre taking Prolia, your healthcare provider will also strongly suggest taking at least 1000 mg of calcium and 400 international units (IU) of vitamin D daily to prevent hypocalcemia or low calcium levels. They can tell you more about benefits and risks of Prolia and Forteo. American Dental Association (ADA) recommendations say that tooth extractions are allowable if needed during Prolia treatment, if both you and your dentist agree. If your dizziness doesnt go away or becomes severe, talk with your doctor. You are encouraged to report negative side effects of prescription drugs to the FDA. Yes, if recommended by your doctor, you can stop taking Prolia. Prolia can cause peripheral edema (fluid retention) or swelling, and this may lead to weight gain in some people. You may report side effects to FDA at 1-800-FDA-1088. Hair loss with Prolia was reported after the drugs initial studies were done and it was approved for use. (With off-label use, a drug is used to treat conditions other than those its been approved to treat.). By stopping RANKL from binding to its receptor Prolia reduces bone breakdown, bone loss, bone pain, and other bone complications. Your doctor will order blood tests to check your level before you start using Prolia and regularly during your treatment. Having a tooth extraction while youre using Prolia may increase your risk for these side effects. Check with your doctor if you have more questions about these drugs. Tingling wasnt specifically reported as a side effect of Prolia in clinical trials. You may wonder how Prolia compares to the medication Zometa. They also include any added costs of the drug being given by a healthcare professional. Follow your doctor's instructions about any restrictions on food, beverages, or activity. Osteoporosis is a condition that weakens your bones, making them more susceptible to fractures. To help prevent low calcium, your healthcare provider may also Some items may interact with your medicine. With osteopenia, your bone mineral density (BMD) is lower than usual. These side effects may be temporary, lasting a few days or weeks. WebIn many individuals, calcium supplements are better absorbed when taken with food. These medications have different active ingredients and they belong to different groups of drugs. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. Nausea can sometimes be a symptom of severe constipation. If you have jaw pain or other mouth problems while youre using Prolia, tell your doctor or dentist. While youre receiving Prolia treatment, your doctor will monitor your cholesterol levels with regular blood tests.
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