post finasteride syndrome myth

Essentially, the cells get too much DHT, it puts them in overdrive and it burns them out. I have had retraction of penis and man boobs. @MariaUloko discusses #postfinasteridesyndrome and #pssd. Therefore, the effects of a subchronic treatment of finasteride.have been evaluated in male rats. One month after the last treatment.changes in neuroactive steroid levels, steroid receptorsand GABA-A receptor subunitswere detected. [T]here is no known treatment for lifelong PFS. VRT-TV, Belgium. Ive made a 80% recovery so far and I keep improving however your hypothesis is quite scary. Im wondering if that Has to do with gut health. Baldness Medication Can Cause Permanent Erection Problems (English translation): De Volkskrant, February 15, 2019. 2021 Dec 13;54(4):422-434. doi: 10.1055/s-0041-1739254. Well, SSRI drugs almost never only inhibit the reuptake of serotonin, but they often also increase allopregnanolone, decrease serotonin receptor sensitivity, block certain serotonin receptors, release dopamine and histamine, etc. [Propecia] is a scary drug and we have no idea who might be affected worse by it. Huh? Then they have no ejaculate. What do you think of TRT is PCT to recover from PFS? Access this article for 1 day for:38 / $45 / 42 (excludes VAT). A growing number of doctors, researchers and therapists have in recent years been voicing their concerns about finasteride's potential to cause persistent physical and mental side effects, known as post-finasteride syndrome (PFS), in a subset of patients. I remember being depressed, emasculated, and hopeless. They see a woman, they say intellectually, I know I am supposed to be interested in you. How much Glycin and Niacinamid do you recommend? There is not a lot of (if any) scientific evidence to backup this up yet, but that doesn't mean that it's non-existent. A growing number of doctors, researchers and therapists have in recent years been voicing their concerns about finasterides potential to cause persistent physical and mental side effects, known as post-finasteride syndrome (PFS), in a subset of patients. I added finasteride to my 2021 list of Drugs to Avoid. A Letter Regarding Finasteride: SouthBayRetina.com, May 2021. Post-finasteride syndrome (PFS) has been claimed to occur in men who have taken oral finasteride to treat either hair loss or benign prostatic hyperplasia, independent of age, dosage, or indication. Also do you recommend an androsterone supplement, I havent heard of that option so far. Post-finasteride syndrome is a non-medical term used to describe a variety of side effects reported by some people who've taken finasteride. Normal T and gonadotropins on lab evaluation. In this episode, Dr. Vikram Jayaprakash and Dr. Russell Knudsen discuss the concept of post-finasteride syndrome. Are Hair-Loss Drugs Safe? 2019 Dec;22(4):250-259. doi: 10.1080/13685538.2018.1548589. 100% agree. As the name suggests, PFS is most commonly associated with finasteride, which was licensed for the treatment of male pattern baldness in 1997. 5-reduced steroids are significantly increased in a hyperthyroid state. Based on the existing body of evidence in the contemporary clinical literature, the author believes that finasteride and dutasteride induce a constellation of persistent sexual, neurological and physical adverse side effects, in a subset of men. It's sold under the brand names Propecia and Proscar. Balding? Statement, via Twitter: November 22, 2022. Long-term-treatment follow-up revealed that (5 mg/day) effects on hair growth are sustained in most women. Treatment with finasteride and dutasteride is thought to potentially improve male pattern baldness. That little pill messed me up pretty good Very few [primary care physicians] are starting proscar or avodart. Int J Trichology. I train a lot, heavy resistance, HIIT, play sport, drink very little. Unable to load your collection due to an error, Unable to load your delegates due to an error. Emerging post-marketing reports of persistent depression and sexual side effects have led to growing concerns about the safety of 5-reductase inhibitors and prompted product labelling changes in many regulatory jurisdictions.1234 Since 2008, at least 17 countries including the United Kingdom and the United States have warned prescribers of the potential for depression, sexual side effects, or both with finasteride.5, Post-finasteride syndrome is an ill defined and controversial syndrome associated with a constellation of sexual, physical, and psychological symptoms that develop during or after finasteride exposure and persist after discontinuation (box 1).35 The incidence of post-finasteride syndrome is unknown, as are the biological mechanisms, but we know that 5-reductase inhibitors reduce synthesis of brain neurosteroids, which affect mood, cognition, and libido.36. Copyright 2023 BMJ Publishing Group Ltd, Brent Area Medical Centre: Salaried GP - Brent Area Medical Centre, Minehead Medical Centre: GP Consultant - Minehead Medical Centre, Meadows Surgery: GP Opportunity (up to 8 sessions) - The Meadows Surgery, Ilminster, Beckington Family Practice: Salaried GP - Beckington Family Practice, Millbrook Surgery: Salaried GP - Millbrook Surgery, Womens, childrens & adolescents health. I found some recovery stories with these compounds. I will never prescribe finasteride. Much of the medical community has yet to recognize [PFS] as a real clinical entity. Dont let any man you know take that poison! And it must be mentioned that there are cases in which these functions are irreversibly impaired, which means there is no recovery after discontinuation of use. The concept of PFS has emerged from reports of non-dermatologists, neuroendocrinological research and reflections, and uncontrolled studies of low quality and with a strong bias selection, while a significant nocebo effect among patients informed about possible side effects of finasteride is recognized. Definitely see this. Post-Finasteride Syndrome: Current Views and Where do We Stand? Playing with your sex hormones with Propecia use can play with your sex life: Pelvic Health & Rehabilitation, July 16, 2015, Nowadays some young men prefer to take fina[steride] AND duta[steride] to try to keep their hair. Now, remember the idea of the testosterone bell curve and damping effects (little testosterone, little growth, more testosterone, more growth, even more testosterone, reduced growth)? I also had dysbiosis in my gut which is slowly being resolved with the help of probitics. Finasteride is a 5-alpha reductase inhibitor that's used to treat androgenetic alopecia (a clinical term for male pattern baldness) and benign prostatic hyperplasia (non-cancerous growth of the prostate gland). Statement, via Twitter: December 4, 2022. Dopamine agonists, such as mucuna pruriens, huperzine A, Catuaba bark extract, etc. Glycine about 5g daily and niacinamide about 500mg-1g daily. Some have petitioned the FDA to include post-finasteride syndrome as a boxed warning. This is the most serious warning given about a medication. Sex Med. Etc Etc In December 2018, I treated scar (not his real name), a 28-year-old man who was distressed by a number of symptoms associated with finasteride, a drug he had been taking for 12 months for alopecia, as prescribed by his dermatologist. By definition, the condition is characterized by sexual dysfunction, somatic symptoms, and psychological disorders that persist after cessation of finasteride treatment. Disclaimer. I think androsterone and allopregnanolone, or topical DHEA and progesterone would be good options. BPH? If topical finasteride causes severe neurocognitive problems, shouldnt we be quite worried about the millions getting the pill form? The https:// ensures that you are connecting to the In a key investigation undertaken at Baylor College of Medicine under Dr Mohit Khera, Howell et al. Altered methylation pattern of the SRD5A2 gene in cerebrospinal fluid of post-finasteride patients: a pilot study: Endocrine Connections, July, 2019. Ruksiriwanich W, Linsaenkart P, Khantham C, Muangsanguan A, Sringarm K, Jantrawut P, Prom-U-Thai C, Jamjod S, Yamuangmorn S, Arjin C, Rachtanapun P, Jantanasakulwong K, Phimolsiripol Y, Barba FJ, Sommano SR, Chutoprapat R, Boonpisuttinant K. Plants (Basel). Statement (via Twitter) in response to Jagan Kansal, MDs tweet, Thoughts on propecia in young guys causing decreased libido, possibly permanent? November 13, 2020. J Sex Med. Response (via Twitter) to medical student Rainy Horowitzs question: What sex-med topics do you think urology residents would most benefit learning about? Post-finasteride syndrome is now a recognized condition, affecting as many as 20 per cent of those taking finasteride.The persistent sexual side-effects of finasteride may manifest after varying periods of taking the drug, or not until the drug is discontinued. Finasteride (Proscar, Avodart, dutasteride) is absolute garbage on a serious note! It can be reversed yes. The most notable finding was that adverse effects persisted in each of the domains, indicating the possible presence of a post-finasteride syndrome., Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride: American Journal of Mens Health, June 13, 2014. After discontinuation, dysfunctions may remain, worsen or resolve. For those who argue that there is no data to support thisAs the saying goes, the absence of evidence is not the evidence of absence. The Top 20 Hair Loss Studies of 2020: Donovan Medical (YouTube), December 11, 2020. Self-reports provide much of our understanding of post-finasteride . Thus, it is inappropriate to dismiss this condition. What Is Post-Finasteride Syndrome? Balding? Side effects thought to be caused by post-finasteride syndrome can be mild or serious. See? In addition, there is a recognized conglomerate of sexual side effects accompanied by neuropsychiatric effects including depression that have been grouped into a term known as post-finasteride syndrome. It's when you lose the regrown hair when you stop taking fin or something? A Pill the Doctor Gave Me Destroyed My Life (English translation): Die Zeit, Feb. 22, 2018. Taking Propecia or Proscar to Prevent Hair Loss is Associated with Depression, Anxiety, and Sexual Problems: National Center for Health Research website, 2021. I have seen some cases of post-finasteride-syndrome that do not revert to anything. Its not to be used without medical supervision. My sides are: The result of the blood test hormone in these patients is generally below the scale or a very low result. VigoraClinic.com, April 30, 2020. We aimed to determine the type and frequency of symptoms in men having long-term sexual and non-sexual side effects after finasteride treatment (a condition recently called post-finasteride syndrome, PFS) against androgenetic alopecia (AGA). People kill themselves after taking [finasteride]I had a colleague who took his own life 15 years ago, so I know it happensand so many people with the same symptoms cant be wrong. Response (via Twitter) to query by Harrison Kalodimos, MD: What are some atypical medication side effects that you have seen in practice and look out for now on a regular basis? April 1, 2021. This site needs JavaScript to work properly. The proportion of men taking 5ARIs and experiencing erectile dysfunction is likely around 5 percent. Adverse Sexual Effects of Treatment with Finasteride or Dutasteride for Male Androgenetic Alopecia: A Systematic Review and Meta-analysis. Health Canada recently recommended adding a warning to products containing [finasteride] While being administered the above-mentioned drug, patients may develop muscle weakness and stiffness, which in turn may cause pain to the patient, damage to muscle tissue and an increase in kinase enzymes. Also its strange. Finasteride is a steroid 5-alpha-reductase inhibitor, approved for the treatment of androgenetic alopecia and benign prostate hyperplasia. A Clinical Overview of Finasteride and Its Potential Causative Links to Long-term Side-effects: The Medical Independent, Jan. 22, 2015. Punk?. I want to try HCG 50 UI per day. My physical and psychological strength is coming back. In my own practice, I see probably a half-dozen patients a year who come in with the observationHey, I was feeling fine, I went on [Propecia], and after that, I noticed these changes in my sexual health. Some men taking Propecia for [male pattern baldness] seem to have little to no side effects, whereas others suffer for years. 2023 Feb 2;12(3):653. doi: 10.3390/plants12030653. [PFS] appears to occur in sensitive individuals, even if exposed to small doses and for short periods, and symptoms can persist for long periods. With a greater concentration of receptors, the organ becomes more sensitive to testosterone and at a certain point, paradoxically, that sensitivity may shut down. Neurosteroids such as 5-DHP and allopregnanolone stimulate neurogenesis, neuronal survival, neuronal differentiation, synaptogenesis, glial differentiation, myelin formation, synaptic function, and synaptic plasticity (, Click to share on Twitter (Opens in new window), Click to share on Facebook (Opens in new window), Click to share on LinkedIn (Opens in new window), Click to share on Reddit (Opens in new window), Click to share on Tumblr (Opens in new window), Click to share on WhatsApp (Opens in new window), The complete guide to maximizing testosterone production to, Improve liver function for a faster metabolism, higher, Why Omega 3 should be avoided and what to use/do instead, How to Optimize Sleep for better Life Performance, 60 Best ways to lower Serotonin (2020 update), Maximize dopamine and live life on cloud nine with laser, How to interpret your testosterone blood results, How to interpret your cortisol test results, How to interpret your thyroid test results, Top 12 must-eat foods to increase testosterone, https://www.amazon.com/product-reviews/B004PVLWW0/ref=acr_dp_hist_2?ie=UTF8&filterByStar=two_star&reviewerType=all_reviews#reviews-filter-bar, From frail and hypogonadal, to gaining 60lbs of muscle, boosting testosterone over 1,000ng/dl and becoming a successful entrepreneur, Apigenin dosage for testosterone: tea is not enough, Bee pollen for erectile dysfunction: the natural sexual booster. In men affected by the PFS, the level of Androstanediol Glucuronide is not restored to previous finasteride levels. Epub 2018 Oct 6. Finasteride is phasing out of my practice. May 21, 2019. Thanks for citing our work [Dr. Faysal]. It is not known why some men are susceptible to the potential adverse effects of finasteride, while othersthe majorityare not affected.Further research is needed on who is susceptible to the persistent, adverse side-effects of finasteride and on the underlying mechanisms of the medication. Lets say your DHT is low, here are the top 7 supplements you can use to increase it: If you want additional methods on increasing DHT apart from supplements, check out my comprehensive article on boosting DHT: If DHT is normal and you still feel off, mainly anxious, not confidence, shy, nervous, experiencing brain fog, etc., you might be low in allopregnanolone. What few people know is that there are 5-R and 3 types of 5-R enzymes and that theyre not only involved in the conversion of testosterone to DHT, but also in the: Many of the benefits of testosterone, such as enhanced insulin sensitivity, reduced catabolism, higher dopamine, increased thyroid hormone production, are mediated by DHT, and blocking DHT production prevents those effects/benefits. (PFS) Post finasteride syndrome is real and affects millions of people worldwide. The .gov means its official. In my opinion, these medications are contraindicated in this population. 8. Mechanisms of finasteride So let's discuss what the drug, finasteride, does in the first place. And thats huge. As we stated in 2006, we advise against a cosmetic product with potential endocrine side effects. Blocking 5 alpha-reductase to any degree in the brain is a crapshoot. As of 2018, 15,000 cases of adverse reactions to finasteride were reported to the WHOwhich is a huge number to begin with. reported gene expression analysis of penile skin samples taken from 26 Post-Finasteride Syndrome patients (median age 38 years) and compared with analysis of samples from 26 control subjects. How do you explain that? The best sex strains. If youve already done blood tests and want to learn how to interpret them, check out these articles: If DHT is high, then you dont have to focus on boosting DHT, but maybe rather allopregnanolone through increasing 5-AR type 1. Plus, his muscles and joints ached It seemed the finasteride was the culprit. We do not capture any email address. 5 Common Medications That Can Cause Erectile Dysfunction: MedShadow, June 9, 2019. Cheers. I have tried a few of the a above already alone with no improvement however I think a holistic combination may be the answer. Based on currently available data, the use of 5-reductase inhibitors in patients with a history of depression, sexual dysfunction or infertility must be carefully and individually evaluated. Acufene Persistent erectile dysfunction in men exposed to the 5-reductase inhibitors, finasteride, or dutasteride: PeerJ, March 9, 2017. Sexual, physical, and overall adverse effects in patients treated with 5-reductase inhibitors: a systematic review and meta-analysis. I will not prescribe finasteride to young men with MPB because of the potential side effects. Thanks for helping people with this truly debilitating syndrome, in my case I was an othewise healthy active 66 year old that was prescribed Dudasteride for an enlarged prostate 3 months ago , after 7 weeks I stopped taking the drug and within several days I came down with a host of symptoms. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). You can send me an email at menelite101@gmail.com with your labs (and any addition info you might deem relevant) so I can take a look. There is accumulating evidence that it negatively impacts male fertility. Post-finasteride syndrome is a rare condition that some men may experience after taking finasteride (Proscar, Propecia). A second 5-reductase inhibitor, dutasteride, was approved in 2001 for benign prostatic hyperplasia. Pills for Hair Growth: YouTube, June 2022. We report the first case of PFS in a long-standing (over 20 years) dermatotrichological practice with frequent finasteride prescription observed in a 25-year-old male following dutasteride treatment for male androgenetic alopecia. Statement (via Twitter) in response to study titled Long-Term Effects of Finasteride on Prostate Cancer Mortality, January 29, 2019. Expanding (via Twitter) on a study published in JAMA Dermatology he co-authored, titled Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride, December 7, 2020. If you stop with fin, then DHT should be back to normal in about 1-2 weeks (tissue binding lasts 4-5 days). Please note: your email address is provided to the journal, which may use this information for marketing purposes. Post finasteride syndrome is so real! These drugs are poison. Some people do have success with HCG, but less so with clomid. Documentary on German network NDR titled Side Effects of Finasteride Are Underestimated: January 25, 2021. Finasteride: NOT a benign drug. As a 5-alpha reductase inhibitor, finasteride works by inhibiting the . So I suggest you continue with Minoxidil and multivitamins. Published by Elsevier Inc. All rights reserved. Good morning, Im starting to find websites like yours with good advice. Accessibility I strong[ly] agree with you, using p=0.06 to [say] that no association between suicide and finasteride is a very careless decision. My biggest issue is low/no libido. If a patient absolutely wants to take finasteride, he must sign a form acknowledging that he has been informed about the side effects and is willing to accept them. Exploring the neural mechanisms of finasteride: a proteomic analysis in the nucleus accumbens, Psychoneuroendocrinology, October 2016. Thanks man, much appreciated. Hi, being a young guy with PFS since 8 months this article has been very helpful to furthermore understand what is possibly going on, so thank you. That may [be] very harmful for the users. As I read websites like yours and CDsNuts. technical support for your product directly (links go to external sites): Thank you for your interest in spreading the word about The BMJ. Bone pain I cant answer. Dont risk your future children for a little hair. Considering the thousands of sufferers who already have PFS, the scientific world immediately needs to conduct more research to determine how to effectively treat this horrible symptom complex. With that in mind, DHT can take anywhere from4 weeks to 2 years or more to recover(R). Statement (via Twitter) to research colleague, Statement via Twitter to fellow clinicians. Im not beholden to trT. PFS can start shortly after starting the medication and can possibly last months to years after stopping. Im 3 weeks off cold turkey. Sexual functioning is returning to some extent. Regulatory Effects of Thai Rice By-Product Extracts from. Chronic insomnia , I am now taking Trazodone which helps me get to sleep, I also have myoclonic twitches and brain zaps while trying to fall asleep and my auditory system is super sensitive any small noise at night makes my me jump even when wearing ear plugs. And they know the risks but prefer the hair. Michael S. Irwig, MD, Attending Endocrinologist, Mohit Khera, MD, Director, Laboratory for Andrology Research, Kian Asanad, MD, Chief Resident Physician in Urologic Surgery, Keck School of Medicine of the University of Southern California, SSMR for the American Urological Association, Professor of Medicine and Public Health, Yale-New Haven Hospital, Roger S. Ho, MD, Associate Professor of Dermatology, Founder, European Institute for Sexual Health, Max Jordan Nguemeni Tiako, MD, Resident Physician, Janet Woodcock, MD, Director of the Center for Drug Evaluation and Research, Urology Resident, Maimonides Medical Center, Brooklyn, New York, Dr. Amin Hussein Al Amiri, Assistant Undersecretary, The United Arab Emirates Ministry of Health and Community Protection, Marc Goldstein, MD, Distinguished Professor of Reproductive Medicine and Urology, Department of Urology, Icahn School of Medicine, New York, Lahey Hospital Medical Center Institute of Urology, Burlington, MA, Advanced Urology Medical, Los Angeles, California, South Bay Retina Ophthalmology Clinic, San Jose, CA, Department of Dermatology, Qassim University, Jeremy B. Sussman, MD, Associate Professor, Internal Medicine, Associate Professor of Medicine, McGill University, Alexander Pastuszak, MD, Assistant Professor of Surgery Urology, VPC Medicina Integrada, So Paulo, Brazil, The Skin Surgery Center. Yes After nearly 4 years of suffering, I have finally & fully recovered from Post Finasteride Syndrome All my symptoms have subsided and improved with this method which takes a while but I am fully functional It's H.C.G (HCG) dosed at 250IU Monday, Wednesday and Friday only.
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